Prescription Drug Coverage

Xtandi® Medicare Coverage

You may be able to find Medicare plan options in your area that cover Xtandi. Learn more about Xtandi and find Medicare Advantage plans in your area that cover prescription drugs.
Chemical name: Enzalutamide

Typical dosage: 40mg

Typical type: Capsule1

Xtandi® is a medication typically used to treat prostate cancer. Xtandi is a brand name only medication and is available as an oral capsule.

Xtandi is a prescription medication that contains the active ingredient Enzalutamide. Xtandi is used to treat prostate cancer that is resistant to medical or surgical treatments (castration resistant) and is given once daily.

Xtandi is an antiandrogen that blocks testosterone and stops the growth of cancer cells by blocking the effects of androgen hormones.

The major side effects of Xtandi include dizziness, tiredness, constipation or diarrhea, hot flashes, signs of a common cold, headache, weight loss, insomnia, anxiety and changes in taste, among others.

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Does Medicare cover Xtandi?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Xtandi.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Xtandi.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Xtandi with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
$3,320 – $13,281 $3,320 – $13,281

Additional information

Your risk of seizures may be increased while taking Xtandi. Your risk for seizures may be higher if you have certain brain blood vessel problems or if you take other drugs that increase the risk of seizures, brain injury, stroke or brain cancer.

Avoid tasks or actions where passing out could cause harm to you or others, and talk to your doctor. The risk of falling is also increased when taking Xtandi.

Use with caution if you have risks for heart disease, including high blood pressure, high cholesterol, being overweight, having high blood sugar or diabetes or smoking cigarettes.

Xtandi interacts with many other drugs. Be sure to talk to your doctor about your full medication list before starting Xtandi.

Xtandi is not indicated for use in females. Male patients with female partners who have the ability to get pregnant should use effective birth control during treatment and 3 months after the last Xtandi dose to avoid harm to the unborn baby.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.