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Prescription Drug Coverage

Xifaxan® Medicare Coverage

You may be able to find Medicare plan options in your area that cover Xifaxan. Learn more about Xifaxan and find Medicare Advantage plans in your area that cover prescription drugs.
Chemical name: Etanercept

Typical dosage: 550mg

Typical type: Tablet1

Xifaxan® is a medication typically used to treat hepatic encephalopathy, irritable bowel syndrome with diarrhea and traveler’s diarrhea. It is available as brand name only in the form of an oral tablet.

Xifaxan is a prescription medication that contains the active ingredient Rifaximin. Xifaxan is usually taken 2 to 3 times daily short term, or chronically depending on the condition being treated.

Rifaximin is a poorly absorbed antibiotic that is active against E. coli bacteria strains that cause diarrhea, and it is believed to reduce intestinal bacteria that produce ammonia in order to treat hepatic encephalopathy.

The major side effects of Xifaxan include headache, dizziness, stomach pain, nausea, feeling tired and weak, muscle spasms, nose or throat irritation and joint pain.

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Does Medicare cover Xifaxan?

Yes! 91% of Medicare Advantage plans and Medicare Part D plans cover Xifaxan.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Xifaxan.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Xifaxan with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
$2,227 – $2,724 $95 – $2,724

Additional information

This medication should only be used for the duration that your doctor prescribes. It can cause secondary infections if used any longer.

If you are taking this medication for traveler’s diarrhea, call your doctor if the diarrhea lasts more than 24-48 hours or if it gets worse.

If you are taking the medication Warfarin, you may need to take extra precaution while simultaneously taking Xifaxan.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.