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Prescription Drug Coverage

Trazodone (Desyrel/Trialodine) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Trazodone, Desyrel or Trialodine. Learn more about Trazodone and find Medicare Advantage plans in your area that cover prescription drugs.
Chemical name: Trazodone

Brand name: Desyrel, Trialodine

Typical dosage: 50mg

Typical type: Tablet1

Trazodone is a medication used to treat major depressive disorder. It is available as a brand name and as a generic and comes as an oral tablet.

Trazodone is an antidepressant medication used to treat major depressive disorder. It is typically taken twice daily, and the dose depends on your response to the drug.

Trazodone increases the amount of available serotonin in your body to help relieve symptoms of depression. The brand name equivalents of Trazodone are called Desyrel and Trialodine.

Major side effects of Trazodone include dizziness, constipation, fatigue, dry mouth, diarrhea, upset stomach, headache, excitability, shakiness, stuffy nose and weight gain or loss.

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Does Medicare cover Trazodone, Trialodine or Desyrel?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Trazodone.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Trazodone.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Trazodone with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
Free – $24 $Free – $24

Additional information

Trazodone should be taken every day. Even if you begin to feel better, do not stop taking Trazodone without talking to your doctor. Stopping Trazodone too quickly can lead to worsening depression and severe side effects.

If you feel sleepy after taking this drug, talk to your doctor. Your doctor may adjust your dose or change what time of day your take the drug. It can take several weeks to feel the full effect of this medication.

If you are taking a short acting formulation of Trazodone, take after a meal or a light snack. If you are on the long acting formulation of Trazodone, take on an empty stomach.

Serotonin syndrome can happen while taking trazodone. Signs of serotonin syndrome includes agitation, change in balance, confusion, muscle twitching, abnormal heartbeat, seizures and more.

Talk to your doctor if you experience these symptoms or any other unusual side effects.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.