Prescription Drug Coverage

Tizanidine (Zanaflex) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Tizanidine or Zanaflex. Learn more about Tizanidine and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Tizanidine

Brand name: Zanaflex

Typical dosage: 4mg

Typical type: Tablet1

Tizanidine is a medication used to treat muscle spasms. It is available as a brand name or a generic and comes as an oral capsule or tablet.

Tizanadine is a medication used to help treat muscle spasms. The brand name equivalent of Tizanidine is called Zanaflex.

Tizanidine should be used only as needed. This medication works by decreasing muscle spasms to help your muscles relax.

Common side effects of Tizanidine include dry mouth, fatigue and dizziness.

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Does Medicare cover Tizanidine or Zanaflex?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Tizanidine.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Tizanidine.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Tizanidine with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
$2 – $41 Free – $41

Additional information

You can take Tizanidine with or without food, but take it the same way each time; either always take it with food or always take it without food.

You should only use Tizanidine at times when muscle relief is most important.

This medication can cause liver problems. Call your doctor if you experience dark urine, dark urine, fextreme weakness, loss of appetite, upset stomach, light-colored stools, vomiting or yellow skin or eyes.

This medication can also cause urinary tract infections (UTIs). Call your doctor if you experience blood in your urine, burning or pain when passing urine, urinating frequently or pelvic pain.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.