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Prescription Drug Coverage

Tizanidine (Zanaflex) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Tizanidine or Zanaflex. Learn more about Tizanidine and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Tizanidine

Brand name: Zanaflex

Typical dosage: 4mg

Typical type: Tablet1

Tizanidine is a medication used to treat muscle spasms. It is available as a brand name or a generic and comes as an oral capsule or tablet.

Tizanadine is a medication used to help treat muscle spasms. The brand name equivalent of Tizanidine is called Zanaflex.

Tizanidine should be used only as needed. This medication works by decreasing muscle spasms to help your muscles relax.

Common side effects of Tizanidine include dry mouth, fatigue and dizziness.

How much does Tizanidine cost with Medicare?

Tizanidine coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Tizanidine?

According to GoodRx, 99% of Medicare Advantage plans and Medicare Part D plans covered Tizanidine in 2023.1

  • Medicare Advantage plans or Part D plans that cover Tizanidine include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2024 Medicare Advantage plans include prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Tizanidine. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

You can take Tizanidine with or without food, but take it the same way each time; either always take it with food or always take it without food.

You should only use Tizanidine at times when muscle relief is most important.

This medication can cause liver problems. Call your doctor if you experience dark urine, dark urine, fextreme weakness, loss of appetite, upset stomach, light-colored stools, vomiting or yellow skin or eyes.

This medication can also cause urinary tract infections (UTIs). Call your doctor if you experience blood in your urine, burning or pain when passing urine, urinating frequently or pelvic pain.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Tizanidine. Retrieved November 2023, from

2 Freed M, et al. (Nov 15, 2023). Medicare Advantage 2024 Spotlight: First Look. Kaiser Family Foundation.