Prescription Drug Coverage

Synvisc Medicare Coverage

Medicare Part B can cover injectable medications administered by a health care provider, such as Synvisc if you meet certain conditions. Learn more and find Medicare Advantage plans in your area that cover Synvisc and other prescription drugs.
Chemical name: Hylan G-F 20

Typical dosage: 16mg/2ml

Typical type: Injection1

Synvisc is a medication typically used to treat osteoarthritis of the knee. It is available as an injection and is brand name only.

Synvisc is a prescription medication usually injected into the knee and should only be administered by an experienced healthcare provider who has appropriate training, experience and knowledge of proper injection technique.

Synvisc is injected once weekly for 3 weeks, for a total of 3 injections.

Synvisc contains the active ingredient hyaluronate, which lubricates and cushions the joint, reducing pain in the knee.

The major side effects of Synvisc include skin discoloration at injection site, bruising, swelling, stiffness and mild pain in or by the knee.

How much does Synvisc cost with Medicare?

If Medicare Part B covers Synvisc treatments for you because you meet the qualifying conditions, you’ll typically pay 0% to 20% of the Medicare-approved amount for the Synvisc prescription price, after you meet your Part B deductible.

In 2024, the Medicare Part B deductible is $240 per year. Once you pay this amount, you’ll pay the remaining copay costs Medicare Part B doesn’t cover.

Does Medicare cover Synvisc?

Medicare Part B covers injectable and infused drugs administered by a medical provider for qualified beneficiaries.

You don’t need a Medicare Advantage plan or a Medicare Part D prescription drug plan to get Synvisc coverage.1

If you have either type of private drug plan, you’re enrolled in Medicare Part B, and you qualify for Medicare coverage of Synvisc, your Part B benefits will cover Synvisc.

Some Medicare Advantage plans and Medicare Part D plans cover other prescription drugs that aren’t administered in a doctor’s office or by a medical professional.

  • Part D plans or Medicare Advantage plans that cover drugs include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2024 Medicare Advantage plans include prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover prescription drugs. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Synvisc is not appropriate for patients who have knee joint infections or skin diseases at the site of injection.

If you receive a Synvisc injection, avoid activity for 48 hours (or as instructed by your doctor). Do not stand on your feet for over 1 hour at a time during the first 48 hours after getting this medication.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Synvisc. Retrieved November 2023, from

2 Freed M, et al. (Nov 15, 2023). Medicare Advantage 2024 Spotlight: First Look. Kaiser Family Foundation.