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Prescription Drug Coverage

Sinemet (Carbidopa/Levodopa) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Carbidopa/Levodopa (generic Sinemet). Learn more about Sinemet and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Carbidopa/Levodopa

Brand name: Sinemet

Typical dosage: 25mg/100mg

Typical type: Tablet1

Sinemet is a medication used to treat Parkinson’s disease. Sinemet is available as a brand name drug or a generic and comes as an oral tablet.

Sinemet is a medication that contains a combination of two active ingredients, Carbidopa and Levodopa. Sinemet increases levels of dopamine in the brain, which is thought to help Parkinson’s disease symptoms.

Sinemet comes as an immediate release tablet that is taken 3-4 times daily or an extended release tablet that is taken 2 times daily.

Common side effects of Sinemet include upset stomach, nightmares, constipation, dizziness, dry mouth, headache and insomnia.

How much does Carbidopa/Levodopa cost with Medicare?

Carbidopa/Levodopa coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Carbidopa/Levodopa?

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans covered Carbidopa/Levodopa, the generic form of Sinemet, in 2023.1

  • Medicare Advantage plans or Part D plans that cover Carbidopa/Levodopa include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2023 Medicare Advantage plans included prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Carbidopa/Levodopa. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

If you are 65 years or older, you may experience more side effects while taking Sinemet. This may cause your urine, sweat and saliva to appear dark red, brown or black. This is normal and should not be a cause for concern.

Sinemet can make you feel very sleepy. Some people who take it have fallen asleep while doing important activities such as driving. This can happen for up to 1 year of starting the drug. If you feel the side effects of becoming especially sleepy, do not drive or do other important tasks.

If you have any fever, muscle cramps, stiffness, dizziness, headache, confusion or abnormal heartbeat, call your doctor. Sinemet can sometimes cause a more serious condition called neuroleptic malignant syndrome, which can cause these symptoms.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.

Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Sinemet. Retrieved October 2023, from

2 Freed M, et al. (Nov 10, 2022). Medicare Advantage 2023 Spotlight: First Look. Kaiser Family Foundation.