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Prescription Drug Coverage

Sertraline (Zoloft) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Sertraline or Zoloft. Learn more about Sertraline and find Medicare Advantage plans in your area that cover prescription drugs.
Chemical name: Sertraline

Brand name: Zoloft

Typical dosage: 100mg

Typical type: Tablet1

Sertraline is a medication used to treat a variety of mood disorders. Sertraline is available as a brand name or as a generic and comes as an oral tablet or an oral liquid.

Sertraline is the generic form of the medication Zoloft.

Sertraline is used to treat major depressive disorder, obsessive compulsive disorder, PTSD, panic disorder, premenstrual dysphoric disorder and social anxiety disorder. It is typically taken once daily, and the dose can depend on your response to the drug.

Sertraline increases the amount of available serotonin in the brain to help improve the symptoms of depression.

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Major side effects of Sertraline include feeling dizzy or weak, constipation, diarrhea, upset stomach, loss of appetite, dry mouth, trouble sleeping, excessive sweating and shakiness.

Does Medicare cover Sertraline or Zoloft?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Sertraline.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Sertraline.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Sertraline with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
Free – $13 $Free – $13

Additional information

Sertraline tablets can be taken with or without food. Capsules must be taken with food.

Even if you begin to feel better, keep taking Sertraline as directed by your doctor. If Sertraline is stopped suddenly, it can cause severe side effects and withdrawal.

Talk to your doctor about slowly stopping Sertraline if you decide you do not want to be on it any longer. It can take up to 4 weeks to begin feeling the effects of this drug.

Serotonin syndrome can happen while taking Sertraline. Signs of serotonin syndrome includes agitation, change in balance, confusion, muscle twitching, abnormal heartbeat, seizures or extreme headaches. Talk to your doctor if you experience these symptoms or any other unusual side effects.

Antidepressants like Sertraline can sometimes cause an increase in the risk of suicidal thoughts and behavior in children and young adult patients. Talk to your doctor if you have worsening suicidal thoughts.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.