Prescription Drug Coverage

Rexulti (Brexpiprazole) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Rexulti (Brexpiprazole). Learn more about Rexulti and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Brexpiprazole

Brand name: Rexulti

Typical dosage: 1mg

Typical type: Tablet1

Rexulti is a medication used to treat depression and schizophrenia. Rexulti is available as a brand name drug and comes as an oral tablet.

Rexulti is a medication that contains the active ingredient Brexpiprazole. Rexulti is used to treat major depressive disorder and schizophrenia.

Rexulti enhances the function of receptors that produce dopamine and serotonin. Increasing dopamine and serotonin helps relieve depression and schizophrenia symptoms. It is typically taken once daily.

Side effects of Rexulti include dizziness, fatigue, restlessness, headache, weight gain and shakiness.

How much does Rexulti cost with Medicare?

Rexulti coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Rexulti?

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans covered Rexulti in 2023.1

  • Medicare Advantage plans or Part D plans that cover Rexulti include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2023 Medicare Advantage plans included prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Rexulti. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Older adults should not take Rexulti to treat mental problems related to dementia.

Rexulti can increase your risk of suicide. Tell your doctor or get medical attention immediately if your depression gets worse, if you experience nervousness, restlessness, grouchiness, panic attacks or other changes in mood.

Let your doctor know if you experience strong urges that are hard to control, signs of a stroke, muscle problems, fever, muscle cramps or stiffness. These symptoms can indicate more serious conditions that require immediate medical attention.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Rexulti. Retrieved October 2023, from

2 Freed M, et al. (Nov 10, 2022). Medicare Advantage 2023 Spotlight: First Look. Kaiser Family Foundation.