Prescription Drug Coverage

Regonol (Pyridostigmine) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Pyridostigmine (generic Regonol). Learn more about Regonol and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Pyridostigmine

Brand name: Regonol

Typical dosage: 60mg

Typical type: Tablet1

Regonol is a medication used to reverse the effects of muscle relaxants and to strengthen muscles. Regonol is available as a brand name or generic drug and comes as an injection.

Regonol is a medication that contains the active ingredient Pyridostigmine. Regonol is used to strengthen muscles and to reverse the effects of muscle relaxants after anesthesia from surgery.

Regonol is typically given in the hospital. It increases the levels of a chemical called acetylcholine in the muscles to improve muscle function.

Side effects are rare when taking Regonol, however upset stomach and muscle cramps can occur.

How much does Regonol cost with Medicare?

If Medicare Part B covers Regonol treatments for you because you meet the qualifying conditions such as receiving Regonol in a hospital, you’ll typically pay 0% to 20% of the Medicare-approved amount for the Regonol prescription price, after you meet your Part B deductible.

In 2024, the Medicare Part B deductible is $240 per year. Once you pay this amount, you’ll pay the remaining copay costs Medicare Part B doesn’t cover.

If you're given a prescription for Pyridostigmine to be administered at home by yourself or a loved one, your prescription for Pyridostigmine may be covered by some private Medicare prescription drug plans. Pyridostigmine coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Regonol or Pyridostigmine?

Medicare Part B covers injectable and infused drugs like Regenol that are administered by a medical provider for qualified beneficiaries.

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans coveedr Pyridostigmine, one generic form of Regonol, in 2023.1

It's important to note that Medicare Part D drug coverage is not required for and can't be used to pay for medication that's administered by a health care professional at a hospital or doctor's office.

  • Medicare Advantage plans or Part D plans that cover Pyridostigmine include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.
  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). [89%] of [2023] Medicare Advantage plans include prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Pyridostigmine. We represent carriers such as Humana, Aetna, UHC, Anthem BCBS, Wellcare, Cigna Healthcare, and Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Regonol is very well tolerated in most people who take it.

Side effects that could indicate a more serious reaction include stomach cramps, vomiting, diarrhea, excess saliva, pupil constriction, sweating, muscle cramps, twitching, weakness and slowed heartbeat.

Regonol is given as an injection into a vein, usually in the hospital. You will be monitored closely after receiving the medication.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Regonol. Retrieved October 2023, from

2 Freed M, et al. (Nov 10, 2022). Medicare Advantage 2023 Spotlight: First Look. Kaiser Family Foundation.