Prescription Drug Coverage

Lisinopril-Hydrochlorothiazide (Zestoretic) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Lisinopril-Hydrochlorothiazide (HCTZ) or Zestoretic. Learn more about Lisinopril-HCTZ and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Lisinopril-Hydrochlorothiazide (HCTZ)

Brand name: Zestoretic, Prinzide

Typical dosage: 20mg/12.5mg

Typical type: Tablet1

Lisinopril-hydrochlorothiazide (HCTZ) is a medication used to treat high blood pressure. Lisinopril-HCTZ is available as a brand name drug or a generic and is an oral tablet.

Lisinopril-hydrochlorothiazide (HCTZ) is a combination of 2 medications used to treat high blood pressure. Lisinopril helps your blood vessels relax while hydrochlorothiazide helps you get rid of sodium to help lower your blood pressure.

The brand name equivalents of Lisinopril-HCTZ include Zestoretic and Prinzide.

This medication is typically taken once daily. The most common side effects of Lisinopril-HCTZ include headache, cough, fatigue and dizziness.

How much does Lisinopril/HCTZ cost with Medicare?

Lisinopril/HCTZ coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Lisinopril/HCTZ?

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans covered Lisinopril/HCTZ in 2023.1

  • Medicare Advantage plans or Part D plans that cover Lisinopril/HCTZ include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2024 Medicare Advantage plans include prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Lisinopril/HCTZ. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Lisinopril-hydrochlorothiazide works to lower your blood pressure, lower your risk of stroke and reduce your risk of heart attack. You won’t be able to immediately feel these benefits of the drug, but you should not stop taking this medication without talking to your doctor.

The lisinopril component of this medication can cause a dry cough that happens within a few months of treatment. Talk to your doctor if this becomes intolerable. The dry cough goes away once treatment is stopped.

Low blood pressure can cause dizziness. If you have severe dizziness or you pass out, talk to your doctor.

Talk to your doctor if you cannot pass urine, you have dark urine, you are extremely tired, you have a loss of appetite or if you have yellow tinted skin or eyes, as it may be indicative of kidney or liver problems.

Do not take this medication if you are pregnant.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.

Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Lisinopril/HCTZ. Retrieved November 2023, from

2 Freed M, et al. (Nov 15, 2023). Medicare Advantage 2024 Spotlight: First Look. Kaiser Family Foundation.