Prescription Drug Coverage

Linzess (Linaclotide) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Linzess (Linaclotide). Learn more about Linzess and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Linaclotide

Brand name: Linzess

Typical dosage: 145mcg

Typical type: Capsule1

Linzess is a medication used for chronic constipation and for treatment of irritable bowel syndrome. Linzess is available as brand-name only and comes as an oral capsule.

Linzess is used to treat general constipation and to treat constipation related to irritable bowel syndrome. It works in the intestine to increase fluid and movement within the bowels.

Linzess is a medication that contains the active ingredient Linaclotide. It is typically taken once daily. Linzess is typically well tolerated, but can lead to stomach pain, diarrhea and signs of a common cold.

How much does Linzess cost with Medicare?

Linzess coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Linzess?

According to GoodRx, 92% of Medicare Advantage plans and Medicare Part D plans covered Linzess in 2023.1

  • Medicare Advantage plans or Part D plans that cover Linzess include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2023 Medicare Advantage plans included prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Linzess. We represent carriers such as Humana, Aetna, UHC, Anthem BCBS, Wellcare, Cigna Healthcare, and Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Take Linzess on an empty stomach at least 30 minutes before the first meal of the day. Do not chew or break the capsule.

If you have trouble swallowing, you can mix the contents of the capsule with applesauce or water. Use the mixture right away and do not chew it.

Linzess should not be used in patients under 18 years of age. Linzess can cause severe dehydration in children that can lead to death.

Let your doctor know if diarrhea becomes severe or if it leads to hospitalization. Signs of significant dehydration due to diarrhea include dizziness, passing out, inability to urinate or extreme fatigue.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Linzess. Retrieved October 2023, from

2 Freed M, et al. (Nov 10, 2022). Medicare Advantage 2023 Spotlight: First Look. Kaiser Family Foundation.