Prescription Drug Coverage

Estrace Medicare Coverage

You may be able to find Medicare plan options in your area that cover Estradiol (generic Estrace). Learn more about Estrace and find Medicare Advantage plans in your area that cover prescription drugs.
Chemical name: Estradiol

Typical dosage: 1mg

Typical type: Tablet1

Estrace is a medication typically used to treat hot flashes, osteoporosis, low estrogen levels in women and advanced prostate cancer. It is available as brand and generic and is an oral tablet.

Estrace is a prescription medication that contains the active ingredient Estradiol. Estrace is an oral medication that is taken one to three times daily depending on the condition being treated.

Estradiol is a type of estrogen and will help relieve symptoms and prevent or treat complications related to low estrogen levels.

The most common side effects of Estrace include headache, hair loss, nausea and vomiting, cramps and bloating, enlarged breasts, breast soreness, vaginal bleeding or spotting and painful periods.

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Does Medicare cover Estrace or Estradiol?

While some Medicare plans may not cover Estrace, 99% of Medicare Advantage plans and Medicare Part D plans cover Estradiol.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Estradiol.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Estradiol with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
$1 – $17 $Free – $17

Additional information

This drug may cause dark patches of skin on your face. Avoid sun, sunlamps and tanning beds as much as possible. Use sunscreen and wear protective clothing and eyewear.

Try to take this drug at the same time of day with or without food. Take it with food if it upsets your stomach.

The use of Estrace may increase the risk of breast cancer in postmenopausal women using conjugated estrogens in combination with medroxyprogesterone acetate. The risk declines once therapy is discontinued.

Estrace is also associated with a higher risk of endometrial cancer in women with uteruses.

Estrogens with or without progestin should not be used to prevent dementia or cardiovascular disease. An increased risk of blood clot, heart attack, pulmonary embolism and stroke has been reported with the use of medications like Estrace.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.