Prescription Drug Coverage

Entresto Medicare Coverage

You may be able to find Medicare plan options in your area that cover Entresto. Learn more about Entresto and find Medicare Advantage plans in your area that cover prescription drugs.
Chemical name: Sacubitril/Valsartan

Typical dosage: 24mg

Typical type: Tablet1

Entresto is a medication typically used to treat heart failure. It is a brand name only medication and is available as an oral tablet.

Entresto is a prescription medication that contains the active ingredients Sacubitril and Valsartan.

Entresto is taken twice daily and the dose is usually increased after 2-4 weeks as tolerated. Entresto relaxes blood vessels so that blood can flow more easily, which makes it easier for the heart to pump blood to the body.

The most common side effects of Entresto include low blood pressure, increased potassium, and a dry cough.

How much does Entresto cost with Medicare?

Entresto coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Entresto?

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans covered Entresto in 2023.1

  • Medicare Advantage plans or Part D plans that cover Entresto include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2024 Medicare Advantage plans include prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Entresto. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

You may not be able to feel the effects of Entresto. Do not stop taking this medicine unless instructed by your doctor.

Low blood pressure can occur with Entresto. Call your doctor if you feel dizzy, weak, or feel like passing out.

Call your doctor if you experience signs of kidney problems including inability to pass urine, change in how much urine is passed, blood in the urine or weight gain.

You should also call your doctor if you have signs of high potassium levels including an abnormal heart beat; change in thinking clearly and with logic; feeling weak, lightheaded or dizzy; feeling like passing out; numbness, tingling or shortness of breath.

Entresto may be combined with other medications to adequately control your heart failure. Entresto should not be used with ACE-inhibitors such as losartan, valsartan or Irbesartan. You may have to delay starting Entresto if you have recently been taking an ACE-inhibitor. 

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.

Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Entresto. Retrieved November 2023, from

2 Freed M, et al. (Nov 15, 2023). Medicare Advantage 2024 Spotlight: First Look. Kaiser Family Foundation.