Prescription Drug Coverage

Divalproex (Depakote) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Divalproex (generic Depakote). Learn more about Divalproex and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Divalproex

Brand name: Depakote

Typical dosage: 500mg

Typical type: Tablet1

Divalproex is a medication used to treat bipolar disorder or focal seizures, and can be used to prevent migraines. Divalproex is available as a brand name or generic drug and comes in a variety of different dosage forms.

Divalproex is a medication that can be used to treat bipolar disorder or focal seizure disorders, and it can be used to prevent migraines. The brand name equivalent of Divalproex is called Depakote.

Divalproex increases the amount of a neurotransmitter chemical called Gamma aminobutyric acid (GABA) in the brain. This helps stabilize mood and gives a nerve-calming effect.

It is available as an oral capsule (immediate- or extended- release), an oral solution (immediate release), an IV injection and as an extended-release tablet.

Common side effects of Divalproex include headache, upset stomach, dizziness, fatigue, constipation, diarrhea, insomnia, weight changes, hair loss and flu-like symptoms.

How much does Divalproex cost with Medicare?

Divalproex coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Divalproex?

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans covered Divalproex in 2023.1

  • Medicare Advantage plans or Part D plans that cover Divalproex include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2023 Medicare Advantage plans included prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Divalproex. We represent carriers such as Humana, Aetna, UHC, Anthem BCBS, Wellcare, Cigna Healthcare, and Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Stopping Divalproex suddenly without talking to your doctor can result in seizures.

If you are taking the capsules or tablets, take your dose with a full glass of water. If you have trouble swallowing pills, there is a “sprinkle” form that can be used in applesauce for easier administration.

Let your doctor know if your mood changes or if your migraines or seizures worsen while taking Divalproex. Also watch for signs of infection including fever, sore throat, cough or chills.

Divalproex can sometimes cause high ammonia levels. Symptoms of high ammonia levels can include a heartbeat that does not feel normal, abnormal breathing, confusion, pale skin, seizures, vomitting or sweating.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Divalproex. Retrieved October 2023, from

2 Freed M, et al. (Nov 10, 2022). Medicare Advantage 2023 Spotlight: First Look. Kaiser Family Foundation.