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Prescription Drug Coverage

Complera Medicare Coverage

You may be able to find Medicare plan options in your area that cover Complera. Learn more about Complera and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate

Brand name: Complera

Typical dosage: 200mg/25mg/300mg

Typical type: Tablet1

Complera is used to treat HIV infection. Complera is available as a brand name only and comes as an oral tablet.

Complera is a medication that includes the active ingredients emtricitabine, rilpivirine, and tenofovir disoproxil fumarate.

Complera is used to treat HIV-1 infection. Complera is taken once daily. Each drug in Complera interferes with the HIV virus’s ability to replicate in the body.

Common side effects of Complera include headache, upset stomach, insomnia, diarrhea, dizziness, strange dreams, fatigue, nose or throat irritation, signs of a common cold and joint and back pain.

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Does Medicare cover Complera?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Complera.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Complera or other HIV medications.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Complera with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
$42 – $2,907 $42 – $2,872

Additional information

Complera should be taken with food. Meal replacement drinks or protein shakes are not sufficient to take with Complera. Even if you feel well, keep taking Complera as your doctor has instructed.

If you have a hepatitis B infection, it can become worse while taking Complera. Be sure to inform your doctor if you have hepatitis B so they can appropriately monitor your liver function.

Avoid taking antacids within 2 hours before or 4 hours after taking Complera. You should also avoid the drugs cimetidine, famotidine, nizatidine or ranitidine within 12 hours before or 4 hours after Complera.

Complera can cause infections to appear that you did not know you had. Talk to your doctor if you experience any signs of infection, even if you have been taking Complera for a long time.

Signs of infection can include fever, sore throat, weakness, cough and shortness of breath.  



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.