Prescription Drug Coverage

Compazine (Prochlorperazine) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Prochlorperazine (generic Compazine). Learn more about Compazine and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Prochlorperazine

Brand name: Compazine

Typical dosage: 10mg

Typical type: Tablet1

Compazine is a used to treat nausea and vomiting. Compazine is available as a brand name or generic drug and comes in many different dosage forms.

Compazine is a medication that contains the active ingredient Prochlorperazine. Compazine is used to manage severe nausea and vomiting.

Compazine stops the release of hormones that can lead to nausea and vomiting. Compazine is available as an injection, a suppository or an oral tablet.

Common side effects include dizziness, nervousness, constipation, dry mouth and fatigue.

How much does Prochlorperazine cost with Medicare?

Prochlorperazine coverage and costs may vary based on the specific plan you have, as well as what coverage stage you're in.

Contact your plan carrier or consult your plan formulary for more cost information.

Does Medicare cover Prochlorperazine?

According to GoodRx, 100% of Medicare Advantage plans and Medicare Part D plans covered Prochlorperazine, the generic form of Compazine, in 2023.1

  • Medicare Advantage plans or Part D plans that cover Prochlorperazine include copay amounts that can range widely from one plan to another. Plan members may also be responsible for meeting a deductible before the plan’s drug coverage kicks in.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). 89% of 2023 Medicare Advantage plans included prescription drug coverage.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Prochlorperazine. We represent carriers such as Humana, UnitedHealthcare®, Anthem Blue Cross and Blue Shield, Aetna, Cigna Healthcare, Wellcare, or Kaiser Permanente.

You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Additional information

Compazine should not be used in older adults to treat mental problems related to dementia.

Muscle problems can happen while taking Compazine. It can become less severe after stopping Compazine but may not go away completely. This risk is greater with higher doses, longer use, in women and in people with diabetes.

Let your doctor know if you experience muscle pain or if you cannot control your body movements.

If you use the suppository, wash your hands before and after use. If the suppository has become soft, put it in the refrigerator or run cold water over it before application.

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This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.

1 GoodRx. Compazine. Retrieved October 2023, from

2 Freed M, et al. (Nov 10, 2022). Medicare Advantage 2023 Spotlight: First Look. Kaiser Family Foundation.