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Prescription Drug Coverage

Bupropion (Wellbutrin) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Bupropion (generic Wellbutrin). Learn more about Bupropion and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Bupropion

Brand name: Wellbutrin

Typical dosage: 75mg

Typical type: Tablet1

Bupropion is a medication used to treat depression and help aid smoking cessation. Bupropion is available as a brand name or generic drug and comes as an oral tablet.

Bupropion is a medication used to treat major depressive disorder and prevent seasonal depression, and it can help as an aid to smoking cessation treatment. The brand name version of Bupropion is called Wellbutrin.

Bupropion is available as an oral tablet that comes in immediate release and extended release forms. The immediate release tablet is typically taken twice daily, while extended release forms are usually taken once daily.

Bupropion increases the amount of norepinephrine and dopamine in the brain to help improve depression.

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Common side effects of Bupropion include dizziness, headache, upset stomach, nervousness, odd dreams, constipation, gas, dry mouth, insomnia, nose or throat irritation and a change in weight.

Does Medicare cover Bupropion or Wellbutrin?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Bupropion.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Bupropion.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Bupropion with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
Free – $22 Free – $22

Additional information

Seasonal depression is also called seasonal affective disorder and is characterized by depressive episodes related to a certain time period of the year when there is less sunshine.

Do not take Bupropion more often than you are told, as this can increase the risk of seizures. If you are taking this medication twice daily, make sure you know how far apart to take your doses. If you have trouble sleeping, take your dose as far away from bedtime as possible. If you take Bupropion once daily, take your dose in the morning.

If you are using Bupropion to stop smoking, let your doctor know if you have not been able to quit after 12 weeks of use.

Thoughts or actions related to suicide can be increased in young adults taking Bupropion. Watch for symptoms of worsening depression and call the doctor right away if this happens.




This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.