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Prescription Drug Coverage

Ampicillin (Principen/Omnipen) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Ampicillin. Learn more about Ampicillin and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Ampicillin

Brand name: Totacillin, Omnipen, Penbritin, Principen, Polycillin

Typical dosage: 500mg

Typical type: Capsule1

Ampicillin is a medication used to treat many types of infections. Ampicillin is available only its generic form, and it comes as an oral capsule, an oral liquid and an injection.

Ampicillin is an antibiotic used to treat many different infections including stomach infections, lung infections, blood stream infections, brain infections and urinary tract infections.

Ampicillin is available in its generic form, though it was once also available as the brand name drugs Totacillin, Omnipen, Penbritin, Principen and Polycillin.

Ampicillin is typically taken multiple times a day and is usually used anywhere from 1-3 weeks or longer. Ampicillin prevents bacteria from forming, which allows your infection to heal.

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Ampicillin is typically well tolerated, but it can cause upset stomach, vomiting and diarrhea.

Does Medicare cover Ampicillin?

Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Ampicillin.1

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.2

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Ampicillin.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Ampicillin with Medicare drug coverage1

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.
$1 – $22 Free – $21

Additional information

Ampicillin should be taken at least 30 minutes before or 2 hours after a meal. Take each dose with a full glass of water. Try to not miss doses, and complete the entire regimen of ampicillin to fully heal your infection.

While diarrhea is common while taking antibiotics, a severe form of diarrhea can occur. Let your doctor know if you have very bad stomach pain or cramps, loose stools or bloody stools.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.