Prescription Drug Coverage

Rexulti (Brexpiprazole) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Rexulti (Brexpiprazole). Learn more about Rexulti and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Brexpiprazole

Brand name: Rexulti

Typical dosage: 1mg

Typical type: Tablet1

Rexulti is a medication used to treat depression and schizophrenia. Rexulti is available as a brand name drug and comes as an oral tablet.

Rexulti is a medication that contains the active ingredient Brexpiprazole. Rexulti is used to treat major depressive disorder and schizophrenia.

Rexulti enhances the function of receptors that produce dopamine and serotonin. Increasing dopamine and serotonin helps relieve depression and schizophrenia symptoms. It is typically taken once daily.

Side effects of Rexulti include dizziness, fatigue, restlessness, headache, weight gain and shakiness.

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Does Medicare cover Rexulti or Brexpiprazole?

Some Medicare Advantage plans and Medicare Part D plans may cover Rexulti.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.1

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Rexulti.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Rexulti with Medicare drug coverage

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in and the Medicare drug plan you have.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.

Additional information

Older adults should not take Rexulti to treat mental problems related to dementia.

Rexulti can increase your risk of suicide. Tell your doctor or get medical attention immediately if your depression gets worse, if you experience nervousness, restlessness, grouchiness, panic attacks or other changes in mood.

Let your doctor know if you experience strong urges that are hard to control, signs of a stroke, muscle problems, fever, muscle cramps or stiffness. These symptoms can indicate more serious conditions that require immediate medical attention.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.