Prescription Drug Coverage

Phenadoz (Promethazine) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Promethazine (generic Phenadoz). Learn more about Phenadoz and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Promethazine

Brand name: Phenadoz

Typical dosage: 25mg

Typical type: Suppository1

Phenadoz is a medication used to treat allergies, nausea, and vomiting. Phenadoz is available as a brand name or a generic and comes as a rectal suppository

Phenadoz is a medication that contains the active ingredient Promethazine. It is used to treat allergies, motion sickness, nausea and vomiting. It can also be used for sedation.

Phenadoz works on many receptors in the body and has antihistamine effects, which is generally the source of the anti-nausea effects.

Common side effects of Phenadoz include fatigue, blurred eyesight, dry mouth, upset stomach and insomnia.

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Does Medicare cover Phenadoz or Promethazine?

While some Medicare plans may not cover Phenadoz, some Medicare Advantage plans and Medicare Part D plans in your area may cover Promethazine.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.1

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Promethazine.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Promethazine with Medicare drug coverage

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in and the Medicare drug plan you have.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.

Additional information

A rectal suppository such as Phenadoz can be an effective alternative when a person is vomiting too much to keep down oral medication. The rectal suppository is still effective if the person taking it vomits after using it, unlike oral forms of generic promethazine.

Wash your hands before and after use. If the suppository is soft, chill in the refrigerator or run cold water over it to firm it up. Take off foil wrapper and insert suppository into rectum gently, pointed end first.  

If you are using Phenadoz for allergies, take the suppository at bedtime. If you use it 3 times daily, take it before meals, then at bedtime.

If you use Phenadoz for motion sickness, use the suppository 30-60 minutes before it’s needed and repeat 8-12 hours later as needed. For other forms of nausea and vomiting, Phenadoz can be used every 4-6 hours as needed.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.