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Prescription Drug Coverage

Linezolid (Zyvox) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Linezolid (generic Zyvox). Learn more about Linezolid and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Linezolid

Brand name: Zyvox

Typical dosage: 600mg

Typical type: Tablet1

Linezolid is a medication used to treat different types of infections. Linezolid is available as a brand name drug or generic and comes as an IV solution, an oral liquid and an oral tablet.

Linezolid is a medication used to treat infections such as pneumonia, skin infections and infections due to bacteria called Enterococcus faecium. It works by stopping the bacteria from replicating in the body, which stops the spread of infection and allows it to heal.

The brand name equivalent of Linezolid is called Zyvox. It is typically given twice daily for up to 3 weeks if needed.

Common side effects of Linezolid include headache, upset stomach, vomiting and diarrhea.

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Does Medicare cover Linezolid or Zyvox?

Some Medicare Advantage plans and Medicare Part D plans in your area may cover Linezolid.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.1

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Linezolid.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Linezolid with Medicare drug coverage

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in and the Medicare drug plan you have.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.

Additional information

While taking Linezolid, consuming some food and drinks (such as cheese or red wine) can cause sudden and severe high blood pressure. Make sure you talk to your doctor about this risk and know what food and drinks you should avoid.

Signs of high blood pressure include dizziness, headache, passing out or changes in eyesight.

Linezolid may increase the amount of acid in your blood. Contact your doctor if you experience abnormal heartbeat, rapid breathing, upset stomach, shortness of breath or muscle pain or cramps.

Linezolid can also lower some blood counts and raise your risk of infection. Signs of infection include fever, chills or sore throat.

Don’t take Linezolid for longer than you have been directed by your doctor, as this can lead to a second infection that involves severe diarrhea.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.