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Prescription Drug Coverage

Keppra (Levetiracetam) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Levetiracetam (generic Keppra). Learn more about Keppra and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Levetiracetam

Brand name: Keppra

Typical dosage: 500mg

Typical type: Tablet1

Keppra is a medication used to treat seizure disorders. Keppra is available as a brand name or generic drug and comes as an injection, an oral liquid and an oral tablet.

Keppra is used to treat focal onset and generalized onset seizures. Keppra is a medication that contains the active ingredient Levetiracetam.

Immediate-release forms of Keppra (tablet, liquid or injection) are typically taken twice daily, while extended release formulations (tablet) are taken once daily.

Common side effects of Keppra include diarrhea, dizziness, fatigue, stuffy nose, upset stomach, headache and flu-like symptoms.

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Does Medicare cover Keppra or Levetiracetam?

While some Medicare plans may not cover Keppra, some Medicare Advantage plans and Medicare Part D plans in your area may cover Levetiracetam.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.1

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Levetiracetam.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Keppra with Medicare drug coverage

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in and the Medicare drug plan you have.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.

Additional information

Keppra can be taken with or without food. Try to take it at the same time of day every day.

If you use the oral disintegrating tablet, do not swallow, chew, break or crush it. Do not use any tablets that have been chipped or broken.

If you have trouble using the disintegrating tablet, you can dissolve it in 1 tablespoon of water and swallow right away.

Seizures can worsen or occur more frequently if Keppra is stopped suddenly without instructions from your doctor. Severe swelling has occurred while taking Keppra, including swelling of the hands, face, lips, eyes, tongue or throat. Get medical help immediately if you experience these symptoms.

It is important to note that Keppra can increase suicidal tendencies, especially in individuals that have experienced this before. Call the doctor immediately if depression occurs or worsens, or if you feel other anxiety or suicidal symptoms.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.