Prescription Drug Coverage

Divalproex (Depakote) Medicare Coverage

You may be able to find Medicare plan options in your area that cover Divalproex (generic Depakote). Learn more about Divalproex and find Medicare Advantage plans in your area that cover other prescription drugs.
Chemical name: Divalproex

Brand name: Depakote

Typical dosage: 500mg

Typical type: Tablet1

Divalproex is a medication used to treat bipolar disorder or focal seizures, and can be used to prevent migraines. Divalproex is available as a brand name or generic drug and comes in a variety of different dosage forms.

Divalproex is a medication that can be used to treat bipolar disorder or focal seizure disorders, and it can be used to prevent migraines. The brand name equivalent of Divalproex is called Depakote.

Divalproex increases the amount of a neurotransmitter chemical called Gamma aminobutyric acid (GABA) in the brain. This helps stabilize mood and gives a nerve-calming effect.

It is available as an oral capsule (immediate- or extended- release), an oral solution (immediate release), an IV injection and as an extended-release tablet.

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Common side effects of Divalproex include headache, upset stomach, dizziness, fatigue, constipation, diarrhea, insomnia, weight changes, hair loss and flu-like symptoms.

Does Medicare cover Divalproex or Depakote?

Some Medicare Advantage plans and Medicare Part D plans may cover Divalproex.

  • Medicare Advantage plans that offer prescription drug coverage are called Medicare Advantage Prescription Drug Plans (MA-PD). Most Medicare Advantage beneficiaries (88 percent) are enrolled in MA-PDs.1

  • Medicare prescription drugs plans each have their own formulary, or drug list, that details what prescription drugs are covered by the plan and how they are covered.

Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Divalproex.

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You can also compare Part D prescription drug plans available where you live and enroll in a Medicare prescription drug plan online when you visit

Average costs for Divalproex with Medicare drug coverage

Your copay and deductible costs for any prescription drug can vary depending on what coverage stage you’re in and the Medicare drug plan you have.

Deductible stage Typical copay stage
Your deductible is the amount of money you must spend on covered drugs before your Medicare drug coverage starts paying its share of costs.

In the deductible stage, you’re responsible for the full cost of your prescription drugs.

Some Medicare prescription drug plans have a $0 deductible. Medicare drug plans cannot have a deductible more than $480 in 2022.
After you meet your Part D deductible, you enter the initial coverage period.

During this phase (the typical copay stage), you pay a copayment (flat fee) or coinsurance (percentage) for your covered medications.

Additional information

Stopping Divalproex suddenly without talking to your doctor can result in seizures.

If you are taking the capsules or tablets, take your dose with a full glass of water. If you have trouble swallowing pills, there is a “sprinkle” form that can be used in applesauce for easier administration.

Let your doctor know if your mood changes or if your migraines or seizures worsen while taking Divalproex. Also watch for signs of infection including fever, sore throat, cough or chills.

Divalproex can sometimes cause high ammonia levels. Symptoms of high ammonia levels can include a heartbeat that does not feel normal, abnormal breathing, confusion, pale skin, seizures, vomitting or sweating.



This article is for informational purposes only. It is not healthcare advice, treatment, or diagnosis. It is not an endorsement of or recommendation for this medication. Speak to your doctor or healthcare provider about your specific healthcare needs, including your prescription medications. Only take medication as directed by your doctor.

Coverage and costs of prescription medications will vary by Medicare plan. Not all plans are available in all areas.


Written by Hayden Gharibyar, Pharm.D.